Recent studies challenge the classical view that the origin of animal life was primarily controlled by atmospheric oxygen levels. For example, some modern sponges, representing early‐branching animals, can live under 200 times less oxygen than currently present in the atmosphere – levels commonly thought to have been maintained prior to their origination. Furthermore, it is increasingly argued that the earliest animals, which likely lived in low oxygen environments, played an active role in constructing the well‐oxygenated conditions typical of the modern (...) oceans. Therefore, while oxygen is still relevant to understanding early animal evolution, the relationships between the two might be less straightforward than previously thought. (shrink)

The use of analogy is an important component of human cognition. The type of analogy we produce and communicate depends heavily on a number of factors, such as the setting, the level of domain expertise present, and the speaker's goal or intent. In this observational study, we recorded economics experts during scientific discussion and examined the categorical distance and structural depth of the analogies they produced. We also sought to characterize the purpose of the analogies that were generated. Our results (...) supported previous conclusions about the infrequency of superficial similarity in subject-generated analogs, but also showed that distance and depth characteristics were more evenly balanced than in previous observational studies. This finding was likely due to the nature of the goals of the participants, as well as the broader nature of their expertise. An analysis of analogical purpose indicated that the generation of concrete source examples of more general target concepts was most prevalent. We also noted frequent instances of analogies intended to form visual images of source concepts. Other common purposes for analogies were the addition of colorful speech, inclusion (i.e., subsumption) of a target into a source concept, or differentiation between source and target concepts. We found no association between depth and either of the other _two_ characteristics, but our findings suggest a relationship between purpose and distance; i.e., that visual imagery typically entailed an outside-domain source whereas exemplification was most frequently accomplished using within-domain analogies. Overall, we observed a rich and diverse set of spontaneously produced analogical comparisons. The high degree of expertise within the observed group along with the richly comparative nature of the economics discipline likely contributed to this analogical abundance. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Letters commenting on Hardwig, J "Is There a Duty to Die?" with a reply to those letters by the author.

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Cambridge History of Seventeenth-Century Philosophy by Daniel Garber, Michael AyersDonald RutherfordDaniel Garber, Michael Ayers, editors. The Cambridge History of Seventeenth-Century Philosophy. 2 vols. Cambridge: Cambridge University Press, 1998. Pp. xii + 1616. Cloth, $175.Over a decade in preparation, this latest addition to the Cambridge History of Philosophy is an enormous achievement—both in its size and the contribution it makes to redefining [End Page 165] the landscape of (...) seventeenth-century philosophy. The editors make no bones about their intention to rewrite the history of early modern philosophy, reversing the trend dominant through much of this century of reading seventeenth-century philosophers in the light of twentienth-century “interests and preconceptions” (4). As they note, the movement to historicize our understanding of seventeenth-century philosophy has been underway for some time in the English-speaking world, furthered in many cases by contributors to these volumes. From this perspective, the present work represents, if not the culmination, at least a progress report on these efforts and the success they have achieved.As in previous volumes of the Cambridge History, the subject matter is treated thematically. Consistent with their larger goal, the editors have further attempted to organize the volumes in a way that remains faithful to the expectations of the period. Part I sets the stage with chapters that establish the larger social and historical context: “The institutional setting” (Richard Tuck); “The intellectual setting” (Stephen Menn); and “European responses to non-European culture: China” (D.E. Mungello). For the rest, the editors write, “the structure of the collection corresponds to one way, at any rate, in which an educated European of the seventeenth century might have organized the domain of philosophy” (2). First comes logic (including method and general ontology); then, the primary categories of being (God, body, soul); finally, the basic operations of the soul (understanding, will, action), whose treatment comprehends the topics of epistemology and ethics.Part II, “Logic, Language, and Abstract Objects,” opens with three short chapters by Gabriel Nuchelmans that survey the terrain of seventeenth-century logic according to the traditional divisions of term, proposition/judgment, and argument. These are followed by contributions on “Method and the study of nature” (Peter Dear); “Universal, essences, and abstract entities” (Martha Bolton); and “Individuation” (Udo Thiel).The discussion of metaphysics proper begins in Part III with the most fundamental being: God. Included here are chapters that examine specific theological issues—“The idea of God” (Jean-Luc Marion); “Proofs of the existence of God” (Jean-Robert Armogathe); “The Cartesian dialectic of creation” (Thomas M. Lennon)—as well as ones that deal more broadly with the crucial connection between philosophy and religion: “The relation between theology and philosophy” (Nicholas Jolley) and “The religious background of seventeenth-century philosophy” (Richard Popkin).Part IV, “Body and the Physical World,” forms the single largest part of the book and its intellectual core. It opens with two chapters—“The scholastic background” (Roger Ariew and Alan Gabbey) and “The occultist tradition and its critics” (Brian Copenhaver)—that effectively mark out the boundaries of the “new philosophy” that emerges in conjunction with the development of seventeenth-century science. These are followed by a series of chapters that examine particular features of that philosophy: “Doctrines of explanation in late scholasticism and in the mechanical philosophy” (Steven Nadler); “New doctrines of body and its powers, place, and space” (Daniel Garber, John Henry, Lynn Joy, and Alan Gabbey); “Knowledge of the existence of body” (Charles McCracken); “New doctrines of motion” (Alan Gabbey); “Laws of nature” (J.R. Milton); and “The mathematical realm of nature” (Michael Mahoney). [End Page 166]The final section of Volume I takes up the third main category of being: “Spirit.” It begins with Daniel Garber’s overview of the positions of the major figures, “Soul and mind: Life and thought in the seventeenth century,” followed by chapters on “Knowledge of the soul” (Charles McCracken); “Mind-body problems” (Daniel Garber and Margaret Wilson); “Personal identity” (Udo Thiel); and “The passions in metaphysics and the theory of action” (Susan James).Volume II of the History is devoted to topics that, in one way or another, elaborate operations of the soul. Part V, “The... (shrink)

Resumo Ensaio expositivo e interpretativo das perguntas sobre a natureza humana e das respostas que o pensamento moderno, em Merlin Donald e outros, vai dando. A perspetiva fisicalista, neurobiológica, é analisada a partir de Joseph LeDoux, e outros, comentando as suas teses principais. É dada ênfase particular à evolução das capacidades da mente humana na transição da cultura mimética para a cultura oral, a criação mítica e o advento da escrita e das outras formas de cultura exterior simbólica. Na (...) crítica ao monismo fisicalista é discutido o que se pode entender por qualia e de que modo este entendimento justifica a aceitação de um “hiato explicativo” como o pensam Urbano Sidoncha e outros autores. É abordada a relação entre Pensamento e Linguagem a partir de Lev Vygotsky. Considerando a ética como um qualia procura-se fixar, empiricamente, a diferença entre ética e eticidade como contraponto à diferença entre autoconsciência e consciência cognitiva. Como proposta final é apresentada uma pergunta radical e oferecida uma temerária resposta sobre o possível conhecimento total da natureza humana. Palavras-chave : autoconsciência, consciência, ética, palavra, qualiaExpository and interpretive essay of the questions on human nature and the responses that modern thought, in Merlin Donald et al., has been producing. The physicalist, neurobiological perspective is analysed as from Joseph LeDoux et al., by commenting on his main theses. Particular emphasis is given to the evolution of the human mind’s capacities in the transition from the mimetic culture to the oral culture, the mythical creation and the advent of writing and the other forms of external symbolic culture. In the critique of the physicalist monism, one discusses what can be understood by qualia and how this understanding justifies the acceptance of an ‘explanatory hiatus’ such as Urbano Sidoncha and other authors think. The relationship between Thought and Language, as from Lev Vygotsky, is addressed. Considering ethics as a qualia, one tries to establish, in an empirical way, the difference between ethics and ethicity in contrast to the difference between self-consciousness and cognitive consciousness. As a final proposition, an extreme question is raised and a daring answer is put forward on the possible full knowledge of human nature. Keywords : awareness, consciousness, ethics, qualia, word. (shrink)

In the eighteenth century the category of the aesthetic sought to bridge the gap between the prevalent dualities of Cartesian thought: art and science, history and science, prejudice and truth. This special issue of _boundary 2_ addresses current debates about the status of art in the context of global modernity. The range of arguments represented here cover a broad historical scope—from Cartesianism to present-day global modernity—of cultural discourse on the aesthetic to bring a focus to contemporary discussions of the corollary (...) concepts of beauty, virtue, taste, and truth. These essays present a rich and provocative account of the place of the aesthetic in late-twentieth-century culture. Included in this volume are considerations of the relation between theories of art and the avant-garde; art’s relation to cognition; the aesthetic as history; the aesthetic as a unique access to modernity; and its impact on problems of identity formation, ideology, and resistances to the institutional powers inherent in dominant social formations. _Contributors. _Charles Altieri, Peter Burger, David Carroll, Anthony J. Cascardi, Howard Caygill, Allen Dunn, Eric Gans, Agnes Heller, Ronald A. T. Judy, Marie-Rose Logan, Daniel T. O’Hara, Donald E. Pease, Alan Singer. (shrink)

Reviewing this collection nearly a year after the deposition of Donald Trump by Joe Biden, one is prompted to delve through memories of a presidency so flagrantly outrageous that it is hard to comprehend that some of the events that took place under it were real. By the final months of Trump's tenure, the coronavirus had brought the United States to its knees, with a death rate then unparalleled anywhere else in the world. Meanwhile, the wave of Black Lives (...) Matter protests, sparked by the brutal killing of George Floyd by Minnesota police, were met with violent military force. The US Army was deployed in cities seen as protest hotbeds, such as Portland, Oregon, and teargas was used to dispel peaceful protesters... (shrink)

According to a common philosophical distinction, the `original' intentionality, or `aboutness' possessed by our thoughts, beliefs and desires, is categorically different from the `derived' intentionality manifested in some of our artifacts –- our words, books and pictures, for example. Those making the distinction claim that the intentionality of our artifacts is `parasitic' on the `genuine' intentionality to be found in members of the former class of things. In Kinds of Minds: Toward an Understanding of Consciousness, Daniel Dennett criticizes that claim (...) and the distinction it rests on, and seeks to show that ``metaphysically original intentionality'' is illusory by working out the implications he sees in the practical possibility of a certain type of robot, i.e., one that generates `utterances' which are `inscrutable to the robot's designers' so that we, and they, must consult the robot to discover the meaning of its utterances. I argue that the implications Dennett finds are erroneous, regardless of whether such a robot is possible, and therefore that the real existence of metaphysically original intentionality has not been undermined by the possibility of the robot Dennett describes. (shrink)

Philosophical tradition sharply distinguishes the conditions under which belief and action are reasonable. This dissertation examines one attempt to sustain this division, namely, the Humean analysis of practical reasons. The Humean analysis divides practical reasons into end and means. The former concerns what one should pursue as goal. The latter, what one should do to realize one's ends. Humeans argue that end reasons are not subject to the conditions of reasonable belief. Since end reasons pick out what has value for (...) an agent, Humeans contend that what makes life meaningful lies largely outside epistemic criteria. I find that Humeans base this claim on two distinct arguments. Each assumes that end reasons are unfit for epistemic appraisal because they lack some feature owned by psychological states suited to epistemic appraisal. A psychological state is fit for epistemic assessment only if its attitude ascribes a truth value to its content and its content owns a truth value. I examine the first conjunct. Regarding , Humeans argue that all genuine end reasons move their agents and, thus, these reasons are wants or take wants as components, since desire is the only source of agent-motivation. But in desiring that p, one does not ascribe a truth-value to p. Thus, end reasons lie outside epistemic criteria, assuming that only those psychological states whose attitude ascribes a truth value to its content are fit for epistemic assessment. Among those who claim that end reasons are a type of conative psychological state in that all genuine end reasons must move their agents are: R. M. Hare, P. H. Nowell-Smith, Gilbert Harman, Donald Davidson, B. A. O. Williams, and Daniel Dennett. I argue that this appeal to motivation fails by examining when an actor is an agent, finding that these conditions do not require that all genuine end reasons motivate. I add that rational failings, such as weakness of will, strongly suggest that not all genuine end reasons motivate. I conclude that end reasons are best conceived as a type of belief and, thus, these reasons do not lie outside epistemic assessment due to their psychological attitude. (shrink)

We distinguish three aspects of medical diagnosis: generating new diagnostic hypotheses, selecting hypotheses for further pursuit, and evaluating their probability in light of the available evidence. Drawing on Peirce’s account of abduction, we argue that hypothesis generation is amenable to normative analysis: physicians need to make good decisions about when and how to generate new diagnostic hypothesis as well as when to stop. The intertwining relationship between the generation and selection of diagnostic hypotheses is illustrated through the analysis of a (...) detailed clinical case study. This interaction is not adequately captured by the existing probabilistic, decision-theoretic models of the threshold approach to clinical decision-making. Instead, we propose to conceptualize medical diagnosis in terms of strategic reasoning. (shrink)

Clinical diagnostic medicine is an experimental science based on observation, hypothesis making, and testing. It is an use dynamic process that involves observation and summary, diagnostic conjectures, testing, review, observation and summary, new or revised conjectures, i.e. it is an iterative process. It can then be said that diagnostic hypotheses are also ‘observation-laden’. My aim is to enlarge on the strategies of medical diagnosis as these are meshed in training and clinical experience—that is, to describe the patterns of reasoning used (...) by experienced clinicians under different diagnostic circumstances and how these patterns of inquiry allow further insight into the evaluation and treatment of patients. I do not aim to present a theory and illustrate it with examples; I wish rather am to let a realistic example, similar to actual clinical scenarios, direct the exposition. To this end, I introduce an account of medical diagnosis—briefly comparing and contrasting it to other accounts—in order to focus on discussing the process of diagnosis through a detailed clinical case. (shrink)

This paper puts forward a general framework for thought about human information processing. It is intended to avoid some of the problems of pipeline or stage models of function. At the same time it avoids the snare of supposing a welter of indefinitely many separate processes. The approach is not particularly original, but rather represents the common elements or presuppositions in a number of modern theories. These presuppositions are not usually explicit, however, and making them so reduces the danger of (...) slipping back into earlier modes of thought.The key point is to distinguish between persisting representations and the processes that translate one representation into another. Various classes or groups of persisting representations can be distinguished by the experimental treatments that interfere with them. In particular, there now seem to be several kinds of short-term or temporary storage, different from each other as well as from longterm memory; the translating processes also have several different modes or kinds. A particularly important aspect of the current position is that a model of this general type no longer requires some external agent to direct and control long sequences of behaviour. (shrink)

So Lentricchia has fulfilled one of his purposes in this essay. He has subverted the patriarchy from within: that is, he has subverted Bloom’s literary history as well as the essentialist feminism associated with it. But he has not fulfilled his affiliated purpose of establishing a dialogue between feminists and feminized males. The “feminization” of literary studies by patriarchal figures like Bloom does not account for the feminization of Stoddard, Gilder, Van Dyke, Woodberry, or Stedman. Their feminization, like that of (...) the Stevens who felt positively lady-like, was not the result of patriarchal oppression. And it will not disappear as the result of the subversion of the patriarchy by a feminized male. Mistaking the work of feminization with the work of the patriarch eradicates the feminine. By identifying the difference between a feminization produced by the patriarchy and a feminine cultural sphere, Lentricchia has made room for the different cultural conversation he wants to develop. But this conversation can take place only after the backdrop of an oppressive patriarch can drop away.This conversation might begin with an account of that cultural sphere in which women are the agency to which Lentricchia alludes. It might begin when we recall that the model for the culture’s “Emmeline Grangerfords” was Harriet Beecher Stowe’s Little Eva. The social change Little Eva helped effect was the emancipation of both slaves and slaveholders. Donald E. Pease is professor of English and American literature at Dartmouth College. His articles on nineteenth-century authors and literature have appeared in a number of journals. He is the coeditor, with Walter Benn Michaels, of American Renaissance Reconsidered, and is the author of Visionary Compacts: American Renaissance Writings in Cultural Contexts, which won the Mark H. Ingraham Prize in 1987. (shrink)

This paper reviews and defends Wittgenstein’s examination of the notion of introspecting psychological states and his critique of introspectionism, in the sense of using reflective awareness as a tool for philosophical or psychological investigation. Its focus is on inner psychological states, like pains or thoughts—it provisionally excludes perceptual states from this category. It approaches the philosopher’s concept of introspection through an analysis of concepts of awareness and self-awareness. It identifies at least two different forms of self-awareness, just one of which (...) is attention to conscious processes. It sides with those who deny that any self-awareness is perception. It outlines and evaluates the primary objections Wittgenstein made to the notion that we can find out about the nature of our mental states through introspection. These objections involve, inter alia, the privacy of psychological states and the inherent fallibility of judgments based on introspective awareness. The critique motivates more cautious and effective psychological investigation of mental states, including proper use of subjects’ introspective reports, and a conceptual approach to the philosophy of mind. Wittgenstein’s reflections prefigure much later views about the problematic nature of introspective knowledge; yet, Wittgenstein receives virtually no mention or credit for this work from contemporary writers. (shrink)

William James, like his father before him, devoted much attention to religion. He defended the human desire to have faith in something, or some being, whose existence could not be empirically defended. Faith generated a feeling of ease and peacefulness, and therefore could be considered a moral good. In The Varieties of Religious Experience James argued that faith could be discovered and enacted in unconventional ways.Mr. Schulte has redefined James’s thesis to support Alcoholic Anonymous 3rd edition. He claims that James (...) provided the germinal idea of the AA program according to the program’s cofounders Bill Wilson and Dr. Bob Smith. Schulte uses Varieties in an adulterate fashion: each of the 8.. (shrink)

Philosophia (Israel), 16(3-4), 333 - 344. YEAR: 1986 Extensive corrigenda Vol. 17, no. 3. -/- SUBJECT(S): Quine's second thoughts on quantifying in, appearing in the second, revised edition of _From a Logical Point of View_ of 1961, are shown to be incorrect. His original thoughts were correct. ABSTRACT: Additional tumult is supplied to pp. 152-154 of _From A Logical Point of View_, showing that being dated is no guarantee of being right. Among other things, it is shown that Quine's argument (...) to the conclusion that limiting the universe of discourse to intensional entities does not "relieve the original difficulty over quantifying into modal contexts" is incorrect; that the contradictory of that conclusion is in fact true; and that an even stronger conclusion is true, with 'abstract' replacing 'intensional'. (shrink)

Proposes the path for understanding human existence developed by M. Merleau-Ponty as a replacement for the paths historically employed by psychology. Descartes established the agenda for modernistic philosophy when he proposed that the task of philosophy is to provide a foundation on which assurances of certain truth can be built. Modernist philosophers diverged, following the paths of sensation and of reason . Postmodernists argue that Descartes's agenda was misguided and that there is no foundation for certain knowledge. They set upon (...) the path of language which led them to the dismissal of the human S. Merleau-Ponty explored the path of the lived body in which thought and extension are intertwined, and along which is located the human S in its temporality and embodiment. The path of embodiment is held to be a more fruitful path than the path of language. 2012 APA, all rights reserved). (shrink)

GRAS is a recently discovered family of plant-specific proteins that play important regulatory roles in diverse aspects of plant development. Several of the motifs present in the GRAS proteins suggest that they function as transcription factors, although homology-searching programs have revealed no significant similarity to any non-plant proteins. Here we propose that the GRAS proteins are related to the Signal Transducers and Activators of Transcription (STAT) family of proteins. STATs are known in many non-plant species, and act as intracellular intermediaries (...) between extracellular ligands and the transcription and activation of genes. Our hypothesis is that the GRAS proteins perform this function in plants, with mechanisms similar to those of the animal STATs. If true, this hypothesis has important implications for the evolution of phosphotyrosine based signal transduction systems in eukaryotic organisms. BioEssays 22:573–577, 2000. © 2000 John Wiley & Sons, Inc. (shrink)